INTEGRATING TRADITIONAL CHINESE MEDICINE-DERIVED NATURAL COMPOUNDS IN THE TREATMENT OF DIABETIC KIDNEY DISEASE AMONG ATHLETES

Authors

  • Pengyu Yao Shandong Laboratory of Engineering Technology Suzhou Biomedical Engineering and Technology Chinese Academy of Sciences, 250101, Jinan, China.
  • Zihan Li Endocrinology department, The first affiliated hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), 250014, Jinan, China
  • Lei Sun Endocrinology department, Qilu Hospital of Shandong University, 250012, Jinan, China
  • Yun Qiao Traditional Chinese Medicine Department, Qilu Hospital of Shandong University, 250012, Jinan, China

Keywords:

Traditional Chinese medicine (TCM), natural compounds, diabetic kidney disease (DKD), chemical structure, mechanism

Abstract

Diabetic kidney disease (DKD) presents as a critical complication in athletes with diabetes, significantly impacting their health and performance. Traditional Chinese Medicine (TCM) offers a treasure trove of natural compounds potentially beneficial in managing DKD. This review delves into the chemistry, mechanisms, and therapeutic potential of TCM-derived compounds in treating DKD among athletes. A total of 35 such compounds have been identified and studied for their roles at various stages of DKD progression. These compounds primarily exert effects by modulating pathways linked to inflammation, apoptosis, and oxidative stress, with the NF-κB, TGF-β, and Nrf-2 pathways being key targets. The review outlines current research trajectories and highlights promising areas for further exploration, suggesting that TCM-derived compounds may offer viable options for mitigating DKD's impacts in athletic populations, thereby supporting both health maintenance and athletic performance.

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Published

2023-02-28

Issue

Vol. 23 No. 90 (2023): Vol. 23, No. 90, junio / June 2023

Section

Manuscript