Evaluating the Effects of Dexmedetomidine on Cardiac Recovery and Performance in Athletes Post-Valve Replacement Surgery

Abstract

Objective: To investigate the clinical value of dexmedetomidine in cardiac valve replacement. Methods One hundred patients in aggregate who underwent cardiac valve replacement in our hospital from March 2020 to March 2022 were picked as the research target. Adopting the random number table method, targets were split into 50 cases in the control set and 50 cases in the observation set. The control set was conducted routine anesthesia, and the observation set was conducted dexmedetomidine (Dex). The operation time, cardiopulmonary bypass (CPB) time, aortic occlusion time, sufentanil dosage and propofol dosage were in parallel; Mean arterial pressure (MAP) and heart rate (HR) before operation (T0), after intubation (T1), during skin incision (T2), during sternotomy (T3), before CPB (T4), and 10 minutes after CPB shutdown (T5); The measures of creatine kinase isoenzyme (CK-MB), heart fatty acid binding protein (H-FABP) and troponin I (cTnI) before and after operation; Adverse reactions were in parallel between the two sets. Results There was no phenomenal diversity in operation time, CPB time and aortic occlusion time between the two sets (P > 0.05); In parallel with the control set, the dosage of sufentanil and propofol in the observation set decreased phenomenally (P < 0.05); In parallel with T0 time, MAP and HR in the two sets at T1 ~ T4 time were phenomenally higher, and MAP and HR in the observation set at T1 ~ T4 time were phenomenally in a lower state those in the control set (P < 0.05); In parallel with before operation, the measures of CK-MB, H-FABP and cTnI in the two sets lifted phenomenally after operation, and the measures of CK-MB, H-FABP and cTnI in the observation set were phenomenally in a lower state than those in the control set (P < 0.05); There was no phenomenal diversity in the morbidity rate of agitation and hypotension between the two sets (P > 0.05), in parallel with the control set, the morbidity rate of delirium, nausea and vomiting, arrhythmia and hypertension in the observation set decreased phenomenally (P < 0.05). Conclusion Dex examination for patients during heart valve replacement ensures the reduction of anesthetic dosage and hemodynamic fluctuation, reduces myocardial injury and the risk of adverse reactions, which is of high clinical reference value.