Exploring the Role of Exercise and Physical Activity in Modifying Imaging Outcomes for Mantle Cell Lymphoma: A Literature Review

Abstract

Objective: This study aims to enhance the diagnostic understanding of mantle cell lymphoma (MCL) by investigating its imaging features and examining the influence of exercise and physical activity on these imaging outcomes. Methods: We conducted a retrospective analysis of clinical data from four confirmed cases of mantle cell lymphoma, diagnosed through lymph node biopsy and pathology, along with a review of related literature. The imaging modalities analyzed included MRI, CT, and PET/CT. Additionally, we reviewed literature concerning the impact of exercise and physical activity on lymphoma progression and imaging findings, hypothesizing that physical activity might alter the typical imaging characteristics of MCL. Results: Imaging in two patients via CT revealed multiple regional lymph nodes with a plain scan CT value of 31 HU and an enhanced CT value of 56 HU, showing no necrosis. Two other patients underwent whole-body PET/CT examinations, which indicated high FDG metabolism in multiple regional lymph nodes. Emerging literature suggests that regular exercise may influence lymphatic system dynamics and possibly the metabolic activity in lymphomas, as observed through imaging modalities like PET/CT. Conclusion: MRI, CT, and PET/CT are highly sensitive in detecting involvement of multiple regional lymph nodes and extranodal organs in MCL. Preliminary literature suggests that exercise and physical activity could potentially modify imaging findings in lymphoma by affecting tumor metabolism and lymph node characteristics. Further studies are required to explore this relationship more deeply, potentially offering new insights into patient management and prognosis in mantle cell lymphoma.