INNOVATIVE TISSUE-ENGINEERED BONE CONSTRUCTS USING LIQUID CRYSTAL COLLAGEN TYPE I FOR ENHANCED RECOVERY IN SPORTS-RELATED INJURIES

Abstract

The development of effective bone regeneration strategies is crucial for athletes experiencing severe or complex bone injuries. This study introduces a novel tissue-engineered bone scaffold designed to enhance the recovery process in sports-related injuries, utilizing a composite of liquid crystal collagen type I and partially deproteinized bone. The scaffold aims to leverage the mechanical robustness and enhanced cellular interaction properties of liquid crystal collagen, coupled with the osteoconductive attributes of partially deproteinized bone. These components are theorized to provide a conducive environment for osteogenesis, potentially resulting in improved bone repair and shorter recovery periods for athletes. The study involved comparative analyses of biomechanical properties, in vitro cellular responses, and in vivo integration and healing efficacy in a controlled animal model. The results indicated superior mechanical strength, increased cellular proliferation, and enhanced osteointegration in scaffolds containing liquid crystal collagen type I compared to conventional materials. The clinical implications of these findings suggest that such advanced scaffolds could significantly impact the management and rehabilitation of bone injuries in sports medicine, offering a pathway to quicker and more effective recovery for athletes. This research underscores the potential of innovative biomaterials to improve outcomes in sports-related injuries, aligning with the goals of advanced therapeutic strategies in sports medicine.