CORRELATION BETWEEN SERUM RBP-4 AND PERILIPIN-5 LEVELS AND PROGNOSIS IN ATHLETIC PATIENTS WITH SEVERE CORONARY ARTERY STENOSIS

Abstract

Objective: To investigate the association of serum RBP-4 and perilipin-5 expression levels and prognosis in people suffering from severe coronary artery stenosis. Methods: The comparing group consisted of 53 athletic patients who had physical examinations at our facility throughout the same time period, and the clinicopathological data of 53 athletic patients with severe coronary artery stenosis medicated in our hospital from January 2020 to June 2022 were retrospectively analyzed as the observation group. The serum RBP-4 and perilipin-5 levels of both groups were compared. The athletic patients were separated into groups with favorable and bad prognoses in order to compare the levels of the blood proteins RBP-4 and perilipin-5 in both groups. In individuals with severe coronary stenosis, the link of blood levels of RBP-4 and utilizing Pearson correlation analysis, perilipin-5 was studied. The diagnostic efficacy of serum RBP-4 was evaluated using receiver operating curve analysis and perilipin-5 in predicting the prognosis of individuals with severe coronary stenosis (ROC). A logistic regression model was utilized to examine the risk variables affecting the prognosis of athletic patients suffering from acute coronary stenosis. Results: The observation group's serum RBP-4 level was greater than the controlling group's, although the controlling group's perilipin-5 level was lower. This discrepancy was clinically meaningful (P < 0.05). The discrepancy of the perilipin-5 level and the good prognosis group was clinically meaningful (P < 0.05). Indeed, the serum RBP-4 level in the group with a poor prognosis was greater than that in the group with a favorable prognosis. According to the findings of a Pearson correlation study, individuals with acute coronary stenosis had a negative association of their blood RBP-4 level and perilipin-5 level (r = -0.550, P = 0.000). The sensitivities were 76.70% and 100.00%, the specificities were 82.60% and 82.60%, and the area under the curves (AUCs) were 0.829 and 0.926, respectively. both serum markers had a greater diagnostic accuracy in predicting the prognosis of athletic patients suffering from acute coronary stenosis, and perilipin-5 performed better than RBP-4. For athletic patients having acute coronary stenosis, age, hyperlipidemia, and RBP-4 can be utilized as independent risk factors, whereas Perilipin-5 is a standalone protective factor that can be utilized. Conclusion: Patients with severe coronary stenosis had considerably up-regulated levels of serum RBP-4 while having decreased levels of perilipin-5. Additionally, perilipin-5 is an independent protective factor impacting athletic patient prognosis, whereas RBP-4 is an independent risk factor affecting athletic patient prognosis. For people having acute coronary stenosis, both serum markers can be utilized as significant indicators to assess their prognosis.