IMPACT OF COMBINED BLOOD PURIFICATION ON COAGULATION, IL-2, AND IL-6 LEVELS IN ATHLETES WITH LIVER FAILURE DUE TO LIVER CANCER

Abstract

Objective: This study aims to evaluate the impact of combined blood purification techniques on coagulation function, and serum interleukin-2 (IL-2) and interleukin-6 (IL-6) levels in athletes with liver failure secondary to liver cancer. Methods: A total of 120 athletic patients with liver failure due to liver cancer, treated at our hospital from March 2019 to February 2021, were selected for the study. They were randomly assigned to either the control group (60 patients), receiving continuous veno-venous hemofiltration (CVVH), or the observation group (60 patients), treated with a combination of CVVH and dual plasma molecular adsorption system (DPMAS). Treatment for both groups lasted for 2 weeks. We assessed the levels of total bilirubin (TBIL), alanine aminotransferase (ALT), γ-glutamyltransferase (GGT), albumin (ALB); coagulation parameters including prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), and fibrinogen (FIB); and serum levels of IL-2 and IL-6. The incidence of complications was also compared between the two groups. Results: Post-treatment, both groups showed significant reductions in TBIL, ALT, and GGT levels, with a significant increase in ALB levels. The observation group had significantly lower levels of TBIL, ALT, and GGT, and higher levels of ALB compared to the control group (P<0.05). Improvements in PT, TT, and APTT, along with an increase in FIB, were observed in both groups post-treatment. The observation group showed significantly better outcomes in these coagulation markers compared to the control group (P<0.05). Serum IL-2 and IL-6 levels decreased significantly after treatment in both groups, with the observation group showing significantly lower levels than the control group (P<0.05). The incidence of complications was comparable between the two groups (P>0.05). Conclusion: In athletes with liver failure due to liver cancer, combined blood purification not only enhances liver function recovery but also significantly improves coagulation function and reduces serum IL-2 and IL-6 levels, without increasing the risk of complications. This treatment approach holds substantial clinical relevance for the athletic population.