INVESTIGATING THE PATHOPHYSIOLOGICAL DEVELOPMENTS IN ATHLETES: A STUDY ON INTESTINAL ULCER PROLIFERATION AND INERT T CELL LYMPHOCYTE TRANSFORMATION IN THE GASTROINTESTINAL TRACT

Abstract

Objective: To explore the pathological evolution from indolent T-cell lymphoproliferative disorder of the gastrointestinal tract (ITLPD-GI) to invasive peripheral T-cell lymphoma (PTCL) within athletes, examining its implications for early diagnosis and intervention in sports medicine. Methods: This study presents an in-depth case analysis from Zhejiang Provincial Hospital of Chinese Medicine, focusing on the progression of ITLPD-GI to PTCL in a professional athlete. The patient's clinical progression, diagnostic challenges, and treatment responses were documented to illustrate the course of the disease and the critical need for awareness among sports health professionals. Results: The case underscores the potential for ITLPD-GI, typically a low-grade, slow-progressing lymphoid tumor, to transform into aggressive PTCL. Diagnostic ambiguity and delayed intervention highlight the necessity for enhanced clinical vigilance and tailored therapeutic strategies in managing such rare pathologies in athletes. Conclusion: This case exemplifies the critical need for sports medicine specialists to consider and recognize rare gastrointestinal lymphoproliferative disorders in athletes, facilitating timely and precise diagnostic and therapeutic approaches to potentially mitigate progression to more malignant forms such as PTCL.