EXPLORING CBL-B PROTEIN EXPRESSION IN BREAST CANCER AND ITS INSIGHTS FOR ENHANCING RESILIENCE TO HIGH-INTENSITY TRAINING IN ATHLETES

Abstract

Objective: This study explores the expression levels of CBL-B protein in breast cancer tissues, aiming to draw insights into its correlation with the physiological stress responses, which could inform strategies for managing stress and recovery in athletes undergoing high-intensity training. Methods: From March 2020 to March 2021, one hundred breast cancer patients treated at our hospital were selected for evaluation. We examined the expression of the CBL-B protein in tumor tissues and compared this with treatment outcomes following neoadjuvant chemotherapy, assessing the protein's potential as a biomarker for stress response. Results: Higher levels of CBL-B protein were observed in breast cancer tissues compared to normal tissues, with significant associations found between CBL-B expression and variables such as histological grade, lymph node metastasis, and tumor stage (P<0.05). Patients with advanced lymph node metastases showed better responses to neoadjuvant chemotherapy, highlighting the protein's role in cellular stress mechanisms. This correlation suggests a potential parallel in athletes, where enhanced CBL-B expression might indicate a heightened adaptive response to physical stress. Conclusions: The findings suggest that higher CBL-B protein expression correlates with increased cellular stress, akin to physiological changes seen in athletes during intense training. Understanding the dynamics of CBL-B in cancer could provide valuable insights into optimizing training and recovery protocols in sports settings, particularly in managing the stress and recovery cycles crucial for athletic performance.