IDENTIFYING THE IMMUNOLOGICAL AND PROGNOSTIC FUNCTIONS OF CCT7 IN PAN-CANCER STUDIES IN ATHLETIC PATIENTS

Abstract

Background: Being a member of the molecular chaperone family, CCT7 plays a critical role in eukaryotic cell development. In a variety of cancers, it plays a key role in the progression and genesis of tumors. CCT7 has been implicated in a number of studies in tumorigenesis, however there has been no systematic analysis of CCT7 in pan-cancer studies. Method: We systematically analyzed the data obtained from the GTEX, TCGA, and TARGET database. An in-depth bioinformatics analysis of CCT7 expression, correlations with clinical prognosis, tumor mutational burden (TBM), microsatellite instability (MSI), mutant-allele tumor heterogeneity (MATH), homologous recombination deficiency (HRD), and tumor immunity was conducted in multiple tumors. The gene mutation of CCT7 in pan-cancer was also examined by spearman correlation analysis. In order to determine if gene sets are functionally enriched, a gene set enrichment analysis (GSEA) has been carried out. Results: Multiple cancers are associated with upregulation of CCT7, which is negatively correlated with prognosis according to a bioinformatics analysis. CCT7 levels is closely linked to TMB, MSI, MATH, HRD, CD4+, CD8+ and DC of immune infiltrating cells in different kinds of cancer. Furthermore, the results of GSEA indicated that CCT7 is involved in the etiology of cancer.  Conclusion: Both tumor immunity and carcinogenesis are mediated by CCT7 in this study. CCT7 may have the potential to serve as a biomarker for the prognosis and immunotherapy for multiple cancers.