IMPACT OF DIETARY FIBER ON GUT MICROBIOTA AND GLYCEMIC CONTROL IN ATHLETIC PATIENTS WITH TYPE 2 DIABETES: A META-ANALYSIS

Abstract

Objective: Disease and diet are closely related, and proper eating habits help regulate gut microbiota. Patients with type 2 diabetes are plagued by disease, and there have been numerous experimental studies on dietary interventions to improve diabetes by regulating gut microbiota. This study will explore the effect of dietary fiber on intestinal microbiota regulation in athletic patients with type 2 diabetes. Methods: In this study, PubMed, PMC, CNKI and other databases were used to screen randomized controlled trials related to the effect of dietary fiber on gut microbiota regulation in type 2 diabetic athletic patients. Then, according to the abstract, keywords and title, the appropriate literature is selected for inclusion. The Cochrane Collaboration Risk Bias Assessment tool was used to evaluate the quality of the included literature. RevMan5.4.1 software was used to conduct a meta-analysis on some indicators of the literature after evaluation. Results: A total of 168 articles were included, among which 49 articles were repeated. After screening, 15 articles were finally selected for analysis. There were 1028 athletic patients in the experimental group and 1030 patients in the control group. The literature not only examined the effect of dietary fiber on the condition of athletic patients with type 2 diabetes mellitus, but also pointed out the role of dietary fiber on the regulation of intestinal microbiota in athletic patients with type 2 diabetes mellitus. Meta-analysis showed that dietary fiber could effectively reduce the levels of total cholesterol (95%CI (-2.60, -0.19), P=0.02 and HDL cholesterol (95%CI (-0.35, -0.05), P=0.009), increased the number of intestinal beneficial bacteria (Firmicutes 95%CI (-0.64, -0.07), P=0.02; Ruminococcus 95%CI (0.27, 0.33), P<0.00001). It also effectively reduced the number of bacteria (95%CI (-0.23, -0.12), P<0.00001). The above findings were statistically significant. Conclusion: According to the included literature, dietary fiber can help alleviate the condition of patients with type 2 diabetes mellitus, and also has a positive regulatory effect on the intestinal flora of athletic patients.