THE EFFICACY OF NICERGOLINE COMBINED WITH YIQI INTELLIGENT DECOCTION IN TREATING SENILE DEMENTIA IN ATHLETIC POPULATIONS: A MEDICAL APPLICATION STUDY

Abstract

Objective: To assess the effectiveness and safety of combining nicergoline with Yiqi Intelligent Decoction in treating senile dementia within athletic patients, focusing on cognitive, psychological improvements, and daily living capabilities. Methods: This study enrolled 138 athletic patients diagnosed with senile dementia, randomly divided into a control group (69 patients) receiving nicergoline treatment, and a research group (69 patients) treated with both nicergoline and Yiqi Intelligent Decoction. Evaluations included Traditional Chinese Medicine (TCM) syndrome scores, cognitive function using MMSE, MoCA, and HDS-R scales, mental health assessments, daily living abilities, overall therapeutic efficacy, and safety profiles through routine health and gastrointestinal function tests. Results: Post-treatment, both groups exhibited improvements in cognitive functions such as intelligence, reaction time, speech, and visual-spatial abilities. The research group showed significantly lower TCM syndrome scores compared to the control group (P<0.05). Cognitive assessments indicated increased scores in MMSE, MoCA, and HDS-R, and a decrease in ADAS-COG scores, reflecting enhanced cognitive performance post-treatment. Safety assessments revealed no abnormalities in routine hematuria, liver, kidney, or gastrointestinal functions in either group. Notably, the incidence of adverse reactions was significantly lower in the research group (7.25%) compared to the control group (15.94%) (P<0.05). Conclusion: The combination of nicergoline and Yiqi Intelligent Decoction presents a significantly effective and safe treatment modality for senile dementia in athletic patients. This therapeutic approach notably improves cognitive functions, psychological well-being, and overall quality of life, demonstrating a lower risk of adverse reactions. The findings advocate for the clinical adoption of this combined treatment strategy in managing senile dementia, particularly in populations with athletic backgrounds, to foster better outcomes in mental and physical health recovery.