EFFICACY AND SAFETY OF TRADITIONAL CHINESE NONPHARMACOLOGICAL TREATMENT FOR POST-STROKE DEPRESSION: A SYSTEMATIC REVIEW AND META-ANALYSIS

Authors

  • Wenrui Zhao Department of Rehabilitation Medicine, The Sixth Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China 510006
  • Genlan Zhang Department of Rehabilitation Medicine, The Sixth Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China 510006
  • Zining Guo Guangzhou University of Chinese Medicine, Guangzhou, China,510006
  • Cui Gao Department of Rehabilitation Medicine, The Sixth Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China 510006
  • Run Lin Department of Rehabilitation Medicine, The Sixth Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China 510006
  • Shaoyang Cui Department of Rehabilitation Medicine, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China 518034

Keywords:

Traditional Chinese Nonpharmacological Treatment, Post-Stroke Depression, Meta-Analysis, Systematic Review

Abstract

Background: Post-stroke depression (PSD) is a mood disorder syndrome that occurs after stroke and is mainly characterized by persistent low mood and decreased interest, accompanied by stroke symptoms. Traditional Chinese non-pharmacological therapies have been gradually and widely used in the clinical treatment of PSD and have shown favorable therapeutic effects. However, no meta-analysis has provided evidence that traditional Chinese non-pharmacological therapies are effective in treating PSD, and the aim of this study was to evaluate the efficacy and safety of traditional Chinese non-pharmacologic therapies for the treatment of PSD. Methods: PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure database, Chinese Biomedical Literature Database [CBM], Chinese Scientific Journal Database [VIP database], and Wan-Fang Database were systematically searched. The primary outcome was the Hamilton Depression Scale (HAMD) score, and the secondary outcome was the effectiveness rate and Barthel Index. After screening the appropriate data, we performed a meta-analysis using the Revman 5.4 software. Results: In this systematic review, 15 randomized controlled trials (RCTs) encompassing 1075 participants were scrutinized. The findings from the meta-analysis revealed that in comparison to standard care, traditional Chinese non-pharmacological treatments were associated with a statistically significant reduction in HAMD scores (P < 0.0001), an improved efficacy rate (P = 0.0006), and a notable enhancement in Barthel Index scores (P = 0.0001). Conclusion: The results of this meta-analysis provide evidence-based data for the use of traditional Chinese non-pharmacological treatments for PSD.

Published

2025-02-06