IMPACT OF HOXA10-AS ON CELLULAR GLYCOLYSIS AND PROLIFERATION IN COLORECTAL CANCER: INSIGHTS INTO ITS CONNECTION WITH SPORTS-RELATED HEALTH AND PHYSICAL ACTIVITY

Abstract

Colorectal cancer remains a significant global health concern, warranting comprehensive investigations into the intricate molecular pathways that underlie its progression. This study delves into the role of HOXA10-AS, a long non-coding RNA, in promoting cellular glycolysis and proliferation in colorectal cancer. Additionally, it explores the intriguing connection between these molecular processes and sports-related health and physical activity, presenting a novel perspective on cancer research. Cellular glycolysis is a pivotal metabolic process that sustains the high energy demands of proliferating cancer cells. In this study, we unveil the critical role of HOXA10-AS in facilitating glycolysis and fostering cancer cell proliferation within the colorectal tumor microenvironment. Through meticulous investigations, we elucidate the molecular mechanisms by which HOXA10-AS mediates GLUT1 mRNA stability via m6A modification, involving IGF2BP2 as a key mediator. Furthermore, this research extends beyond the confines of cancer biology to explore the implications of these molecular interactions for individuals engaged in sports and physical activities. Physical fitness and well-being are integral components of a healthy lifestyle, and understanding the molecular underpinnings of cancer progression in the context of sports-related health becomes paramount. This study initiates a dialogue between the fields of oncology and sports science, raising questions about how physical activity may influence the molecular landscape of cancer. The findings presented herein illuminate the intricate web of molecular interactions involving HOXA10-AS, glycolysis, and cancer proliferation. Moreover, they offer a novel perspective on the potential impact of sports-related health and physical activity on cancer biology. While further research is needed to fully grasp the implications of these connections, this study lays the foundation for a broader exploration of the relationship between lifestyle choices, cancer development, and overall well-being, bridging the gap between cancer research and sports-related health.