PROGRESS IN METALLOMATRIX PROTEINASES IN RHEUMATOID ARTHRITIS

Abstract

Chronic synovial inflammation is a hallmark of rheumatoid arthritis (RA), an inflammatory illness that causes bone and articular cartilage to deteriorate, ultimately leading to joint deformity and dysfunction. Studies have shown that metallomatrix proteases (matrix metalloproteinases, MMPs) are associated with the progression of RA. MMPs mainly participate in the progression of RA by destroying joint tissue, generating residual epitopes, and regulating inflammatory processes. The understanding of the role and regulatory mechanisms of MMPs can provide new strategies for the treatment of RA. In this paper, we reviewed the treatment of RA by selective inhibition of the mechanism of action nodes by explaining the progress of MMPs in the pathogenesis of RA.