ROLE OF GENETIC INHERITANCE FACTORS IN ATHLETIC RECOVERY AFTER KNEE ARTHROPLASTY AND ANALYSIS OF MENDELIAN RANDOMIZATION

Abstract

Objective: To study the specific role of gene genetic factors in the exercise recovery after knee arthroplasty and to explore the genetic expression of knee patients. Methods: The cartilage tissues of 40 patients who underwent knee surgery in the First Affiliated Hospital of TJ Medical College were used as the study samples, which were divided into TKA group and CON group, and set up different protocols of postoperative exercise program to record the NRS scores, recovery, and knee function of the patients of different groups in the postoperative period. Then Mendelian randomization analysis was combined to study the gene sensitivity and differential gene expression of knee patients. [Results] Compared with the CON group, the NRS pain scores at rest and during activity were significantly lower in the TKA group (P<0.05), and the time to first standing on the ground was significantly lower in the TKA group (22.18±3.26h) than in the CON group (30.38±9.45h), with significance test results possessing differences (P<0.05). Under the condition of 2-fold gene differential expression, there were 165 and 63 genes that were significantly up-regulated and down-regulated in the cartilage tissues of TKA patients, respectively. Conclusion: The postoperative recovery of knee joint patients can be significantly enhanced by postoperative exercise recovery, which promotes the differentiation of cartilage tissues in the osteogenic direction and enhances the proliferation of osteoblasts in the knee joints of patients with TKA.