THE EFFECT OF EXERCISE MODALITIES ON INFLAMMATORY MARKERS IN PATIENTS WITH RHEUMATOID ARTHRITIS: A META- ANALYSIS

Abstract

To compile the available data and measure how physical exercise affects vascular structure and function in autoimmune rheumatic disorders (ARDs). Clinical studies assessing the impact of physical activity treatments on indicators of macrovascular anatomy and microvascular function in ARDs were found by searching databases until March 2020. Using Hedges' g, random effects meta-analysis was used to aggregate the studies. The research study based on primary data analysis for determine the research used Smart PLS software and generate result included descriptive statistic, correlation coefficient also that smart PLS Algorithm model between them. The following outcomes were subjected to meta-analyses: macrovascular structure (aortic pulse wave velocity (PWV)), microvascular function (skin blood flow or vascular conductivity responses to acetylcholine (ACh) or sodium nitroprusside (SNP) administration), and macrovascular function (brachial flow-mediated dilatation (FMD%) or brachial responses to glyceryl trinitrate (GTN%)). This review included 10 studies with a total of sixty participants. Overall, the available clinical trials showed that physical exercise improved microvascular and macrovascular function indicators in ARD patients, but not macrovascular structure. The wide-ranging positive effects of exercise on the vasculature found in this analysis provide credence to its use as a successful non-pharmacological treatment approach for ARD patients.