CLINICAL APPLICATION OF MULTI-SLICE SPIRAL CT TO DETERMINE CORONARY ARTERY CALCIFICATION SCORE IN ELDERLY CORONARY HEART DISEASE RISK FACTORS ASSESSMENT

Abstract

Objective: To investigate the clinical application of multislice spiral CT to determine coronary artery calcium score (CACS) in the assessment of coronary heart disease risk factors in the elderly. Method: A total of 336 elderly patients with coronary heart disease admitted to our hospital from February 2021 to February 2023 were selected as the study objects. All patients received coronary artery enhancement scan with multislice spiral CT (MSCT). According to Agatston score, they could be divided into calcification negative group (CACS =0, n=82) and calcification positive group (CACS > 0, n=254). The calcification positive group was subdivided into mild calcification group (0<CACS<100, n=142), moderate calcification group (100≤CACS<400, n=64) and severe calcification group (CACS≥400, n=48) according to the correlation between calcification score and cardiovascular disease risk. Basic data and blood biochemical data of all subjects were collected, and clinical data of calcification negative group and calcification positive group were compared. The clinical data of elderly patients with coronary heart disease with different CACS were compared. Multivariate Logistic regression equation was used to analyze the related indexes of coronary heart disease in elderly patients with different CACS. Classification criteria of calcification scores and risk prediction of coronary heart disease by each score segment. Results: The levels of age, smoking history, drinking history, systolic blood pressure, diastolic blood pressure, GLU, TC, TG, LDL-C, PLR and NLR in calcification positive group were significantly higher than those in calcification negative group (P<0.05). There were statistically significant differences in age, GLU, LYM, PLR and NLR in elderly patients with coronary heart disease with different CACS. The levels of age, GLU, PLR and NLR gradually increased with the increase of calcium score, while the levels of LYM and NLR gradually decreased with the increase of calcium score (P<0.05). Multivariate logistic regression analysis showed that age, TG and PLR were independent risk factors for CACS (P<0.05). The risk of cardiovascular disease was higher in patients with moderate and severe calcification, especially in patients with severe calcification. Conclusion: CACS is closely related to age, TG and PLR in elderly patients with coronary heart disease. CACS can be used as an important scientific basis for the diagnosis, prevention and risk assessment of coronary heart disease.