HER2- BREAST CANCER: A COMPARATIVE STUDY OF THE COMBINED DIAGNOSTIC VALUE OF MRI AND DM (A CLINICAL ANALYSIS OF 160 SUSPECTED PATIENTS)

Abstract

Objective: The purpose of this study was to evaluate the value of magnetic resonance imaging (MRI) in combination with digital mammography (DM) in the diagnosis of human epidermal growth factor receptor 2-negative breast cancers (HER2- BC). Methods: Clinical data of 210 patients with suspected HER2- BC were collected. The differences in sensitivity, specificity, accuracy, and diagnostic efficacy were analyzed by comparing the diagnostic results of MRI and DM. A detailed clinical examination, including DM and MRI, was performed on all patients. All imaging findings were independently interpreted by five experienced radiologists and then assessed for consistency. Results: In a comprehensive analysis of 210 BC cases, the cohort was segregated into two distinct subgroups: 160 cases diagnosed with HER2-BC and 50 cases characterized by non-HER2-BC profiles. Statistical significance was observed only in the maximum lesion diameter, peritumoral edema, and prothoracic edema among the three groups (P < 0.05) 。MRI images showed lower homogeneity and blurring in patients with HER2- BC, in contrast to DM images, which showed slight calcification and structural abnormalities. The AUC value of the combination of MRI and DM for the diagnosis of HER2- BC was found to be significantly higher than that of either test alone (P=0.005), as analyzed by the subject's workup characteristic (ROC) curve. The combined diagnosis achieved an accuracy of 97.14%, a sensitivity of 98.75% and a specificity of 97.53%. Conclusion: The combined diagnosis of MRI and DM can complement each other and improve the diagnostic efficacy of HER2- BC.