Exploring the Impact of Physical Activity on ARMC12 Overexpression in Clear Cell Renal Cell Carcinoma: Insights for Improved Clinical Outcomes

Abstract

Renal cell carcinomas (RCC) represent approximately 90% of all kidney cancers, leading to 403,300 new cases and 175,100 deaths globally in 2018. Among these, clear cell renal cell carcinoma (ccRCC) emerges as the most prevalent and lethal subtype, accounting for 80% to 90% of RCC cases. Characterized by resistance to radiotherapy and traditional chemotherapy, ccRCC typically forecasts a dire prognosis, underscoring the urgent need for novel biomarkers and therapeutic targets. Advancements in high throughput sequencing have dramatically enhanced our ability to analyze the transcriptome and genome swiftly and economically, yet the roles and mechanisms of many genes remain obscure, particularly those affecting the immune microenvironment in ccRCC. This study focuses on ARMC12, a gene implicated in ccRCC pathogenesis and progression, to elucidate its overexpression and clinical relevance. Moreover, we integrate the potential influence of physical activity, a modifiable lifestyle factor known to affect gene expression and immune function. Recent evidence suggests that regular physical activity might modulate the expression of cancer-related genes and improve immune surveillance, thereby potentially altering the progression and therapeutic response of ccRCC. This research aims to establish a link between physical activity levels and ARMC12 expression, evaluating whether exercise can serve as a complementary strategy to enhance the prognosis of ccRCC patients. Through integrating molecular biology with lifestyle factors, we strive to uncover actionable insights that could lead to more personalized and effective therapeutic approaches for ccRCC.