MODULATION OF IMMUNE STATUS IN PATIENTS WITH MEMBRANOUS NEPHROPATHY BY DIFFERENT EXERCISE PATTERNS

Abstract

Objective: With the increasing importance of lifestyle intervention in chronic disease management, the application of exercise as a non-pharmacological treatment in patients with membranous nephropathy has gradually received attention. Methods: Patients with idiopathic membranous nephropathy confirmed by renal biopsy in a hospital from January 01, 2018 to June 2023 were selected as the study subjects and were divided into four groups according to the different modes of exercise, fitness gong exercise group, aerobic training exercise group, high-intensity interval training group, and irregular exercise group. Epidata 3.1 and SPSS 24.0 were used for data processing and analysis to compare the differences in demographic characteristics, clinical characteristics and daily life behaviors of patients with membranous nephropathy with different exercise modes, as well as the modulating effect of different exercise modes on the immune status of patients. Results: Fitness gong exercise had the highest remission rate of membranous nephropathy patients, with the remission rate as high as 79.36%. The urinary protein conversion rate of membranous nephropathy patients with aerobic training exercise was as high as 99.84%, with remarkable recovery effect. In contrast, the urine protein conversion rate of membranous nephropathy patients with HIIT and irregular exercise was lower, 60.32%, 60 days and 25%, respectively. Fitness gong exercise and aerobic training exercise had a positive effect on immune function in patients with membranous nephropathy, with regression coefficients of 0.20 and 0.25, respectively, and P values were significant, whereas HIIT and irregular exercise might aggravate renal burden. Conclusion: This study reveals the effects of different exercise modes on renal filtration function in patients with membranous nephropathy and provides a scientific basis for the mechanism of action in the adjuvant treatment of membranous nephropathy.