EXPLORING THE RELATIONSHIP BETWEEN SYMPTOM SEVERITY AND BIOMARKERS IN ATHLETIC PATIENT WITH NEWLY DIAGNOSED SCHIZOPHRENIA: FOCUS ON 25-(OH)D, HCY, AND AUTOIMMUNE THYROID INDICATORS

Abstract

Background: This study aims to investigate the association between serum 25-hydroxyvitamin D [25-(OH)D], homocysteine (Hcy), and autoimmune thyroid indices with the severity of initially diagnosed schizophrene symptoms. Methods: 100 cases of initially diagnosed schizophrene athletic patients admitted between January 1, 2019, and December 31, 2023, were enrolled as the initially diagnosed schizophrene group, while 50 healthy volunteers were selected as the healthy control group. We compared general clinical information, relevant assessment scales, and laboratory parameters from the two groups of participants. Pearson's correlation analysis was employed to evaluate the relationship between the severity of symptoms and 25-(OH)D, Hcy and thyroid autoimmune indices. A multiple linear regression analysis was performed to predict the assessment of negative (SANS) and positive (SAPS) symptoms scores. Results: 25-(OH) D was negatively correlated with negative (r = -0.718, P < 0.001) and positive symptoms (r = -0.360, P = 0.032). Hcy was positively correlated with negative symptoms (r = 0.540, P < 0.001), but not with positive symptoms (r = 0.167, P = 0.096). TG-Abs was unrelated to both negative (r = -0.132, P = 0.190) and positive symptoms (r = -0.019, P = 0.850). TPO-Abs was positively correlated with negative symptoms (r = 0.309, P = 0.002), but not with positive symptoms (r = 0.185, P = 0.065). 25-(OH) D and Hcy were independent influencing factors for changes in the SANS scores (all P < 0.001). Conclusions: 25-(OH)D, Hcy, and TPO-Abs levels might serve as potential markers for the severity of symptoms in initially diagnosed schizophrene.