BRAIN-CARDIAC CROSSTALK IN ISCHEMIC STROKE:MECHANISTIC DISSECTION

Abstract

Stroke is the second leading cause of death and a major contributor to disability worldwide. 80% of strokes are ischaemic, which places a heavy burden on society due to its complex pathogenesis and difficulty in treatment. Therefore, it is essential to develop measures to reduce the incidence of ischaemic stroke and its harmful consequences. This article provides an overview of ischaemic stroke, including its definition and classification. It then examines the inflammatory response during ischaemic stroke and the brain-mind crosstalk mechanisms of the neuroendocrine-vascular axis. Finally, it discusses intervention strategies that target the brain-mind axis. The inflammatory response is a significant pathological manifestation of ischemic stroke. It has a profound effect on the brain and also plays a crucial role in the heart through the circulatory system. This review aims to provide a new integrated perspective on the brain-cardiac crosstalk in the context of ischaemic stroke by uniting and combining the hypothalamic-pituitary-adrenergic axis (HPA axis), the autonomic nervous system, the renin-angiotensin-aldosterone system (RAAS), and the natriuretic peptide system into a neuroendocrine-vascular axis as a bridge between the brain and heart connections and integrating them into the mechanism of inflammatory response.