IMPACT OF A MODEL OF ORAL NUTRITIONAL SUPPLEMENTATION COMBINED WITH INDIVIDUALIZED PARENTERAL NUTRITIONAL SUPPORT DURING THE PERI-TRANSPLANTATION PERIOD OF AUTOLOGOUS HEMATOPOIETIC STEM CELLS ON PATIENTS

Abstract

Purpose: Poor nutrition status before and during transplantation is associated with poor prognosis in patients undergoing autologous stem cell transplantation (ASCT). A standardized strategy for nutritional support of patients undergoing ASCT is lacking in many centers; therefore, we designed this study to analyze the impact of a model of oral nutritional supplementation (ONS) combined with individualized parenteral nutritional (PN) support for patients during the peri-transplantation period of ASCT. Methods: In this retrospective clinical study, a total of 60 study subjects (30 cases in the traditional group and 30 cases in the individualized group) were enrolled from February 2022 to August 2023, and demographic and clinical information was collected from the two groups of patients. Nutritional outcomes (weight change, serum total protein, serum albumin) and clinical outcomes (hospital time, platelet engrafment time, neutrophil engrafment time) were compared between the two groups. Results: Both groups experienced weight loss during transplantation, but the individualized group experienced less weight loss (-3.78±2.32 vs -2.39±2.57, P=0.032), serum total protein (-6.80±8.19 vs -3.83±7.99, P=0.161) and serum albumin (-5.75±4.85 vs -4.46 ±6.56, P=0.389) were not statistically different between the two groups. There was a statistical difference in the length of hospital stay between the two groups (30.20±9.37 VS 26.43±3.91, P=0.047), the engrafment time of platelets (15.40±2.92 VS 14.50±3.32, P=0.269), and the engrafment time of neutrophils was (11.07±1.66 VS 11.23, P=0.741) no statistical difference. Conclusion: The paradigm of ONS combined with individualized PN support during the peri-transplantation period of ASCT positively affects both clinical outcomes and nutritional outcomes of patients and improves the prognosis of patients undergoing ASCT.