TUMOR TYPING OF ANOIKIS-RELATED GENES AND PROGNOSTIC ANALYSIS OF ANOIKIS IN DIFFUSE LARGE B-CELL LYMPHOMA

Abstract

Diffuse large B lymphoma is the most prevalent tumor among non-Hodgkin's lymphomas, which is difficult to detect in early stages, refractory to treatment and has a high relapse rate. anoikis has been classified as a specific apoptotic pathway utilizing signaling, and increasing evidence suggests that Anoikis-related genes thereby altering the immune microenvironment of tumors as well as preventing the spread and metastasis of cancer cells, which may guide clinical immunotherapy. Therefore, we obtained two subtypes associated with anoikis by consensus clustering analysis. Meanwhile, we analyzed and established a prognostic risk model based on the GEO cohort, which includes 20 genes. And it has been validated in both in vivo and in vitro. This study established a DLBCL classification criterion based on anoikis features. Additionally, this categorization is essential clinically for determining the treatment and prognosis of DLBCL sufferers.