THE ROLE OF PAR3 IN GASTRIC CANCER: IMPLICATIONS FOR ATHLETES AND FITNESS ENTHUSIASTS

Abstract

The objective of this study is to elucidate the role of Partitioning-defective 3 (Par3) in the development of gastric cancer and its correlation with different gastric cancer tissue types, particularly considering the health implications for athletes and fitness enthusiasts. From January 2019 to January 2022, 180 gastric cancer specimens, post-surgical resection, were analyzed (group B), with gastric mucosa tissue serving as a control (group A). Immunohistochemical methods assessed Par3 expression across various parameters, including tissue layer, invasion depth, tissue type, and lymph node metastasis. Key findings include a significant decrease in Par3 expression in cancer tissues compared to controls (P<0.05), no significant difference in Par3 expression between early (T1+T2) and advanced (T3+T4) stage patients (P>0.05), and similar findings regarding lymph node metastasis. Notably, Par3 expression was markedly lower in gastric type cancer than in intestinal or mixed types (P<0.05). Kappa consistency analysis indicated a significant correlation between Par3 down-regulation and gastric-type cancer (kappa=0.416), but not with other types (kappa=-0.270, -0.087). The study concludes that Par3 down-regulation is vital in gastric cancer development, particularly in gastric-type cancer, suggesting its potential as an auxiliary diagnostic marker. For athletes and fitness enthusiasts, these findings underscore the importance of monitoring gastric health, as disruptions in gastric function can significantly impact physical performance and overall well-being.