EXPLORING THE ROLE OF ANGIOTENSIN-(1-7) IN MITIGATING BRAIN INJURY POST-CARDIAC ARREST: IMPLICATIONS FOR ATHLETE RECOVERY AND MENTAL HEALTH

Authors

  • Li Zhu Department of Anesthesiology, Chengdu Jinniu District People’s Hospital, Sichuan, 610000, China
  • Qisong Yuan Department of Anesthesiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Hubei, 435000, China
  • Lan Wang Department of Anesthesiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Hubei, 435000, China
  • Run Wang Department of Anesthesiology, Chengdu Jinniu District People’s Hospital, Sichuan, 610000, China
  • Xia Zhou Department of Emergency, Guizhou Provincial People's Hospital, Guizhou, 550499, China
  • Ke He Department of Anesthesiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Hubei, 435000, China

Keywords:

Cardiac arrest-cardiopulmonary resuscitation; Brain injury; Ang-(1-7); Brain edema.

Abstract

Objective: This study investigated the effectiveness of Angiotensin-(1-7) [Ang- (1-7)] in reducing brain injury in rats after cardiac arrest and cardiopulmonary resuscitation (CA-CPR), with potential implications for athlete recovery and mental health. Design: Using a rat model of ventricular fibrillation-induced CACPR, we monitored heart rate (HR) and mean arterial pressure (MAP), analyzed brain tissue pathology, and measured cerebral moisture and serum markers of brain injury. Results: Post-CPR, Ang-(1-7) treatment was associated with improved HR and MAP, reduced brain edema, and decreased levels of brain damage markers (3-nitrotyrosine and S100B). Furthermore, Ang- (1-7) modulated the expression of AT1R and Mas receptors in brain tissue, indicating its neuroprotective mechanisms. Conclusions: Ang-(1-7) shows promise in mitigating brain injury post-CA-CPR by regulating key receptors and reducing inflammation and edema. This suggests potential benefits for managing brain health in athletes recovering from severe circulatory events.

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Published

2023-03-31

Issue

Vol. 23 No. 89 (2023): Vol. 23, No. 89, marzo/March 2023

Section

Manuscript