EFFECTS OF VITAMIN D3 COMBINED WITH PROBIOTICS ON ANTIBIOTIC-ASSOCIATED DIARRHEA SECONDARY TO CHILDHOOD PNEUMONIA IN CHILD PLAYERS: A STUDY ON PHYSICAL FITNESS AND MENTAL HEALTH OUTCOMES

Abstract

Objective: This study aimed to evaluate the efficacy of Vitamin D3 combined with probiotics (Bifidobacterium triple live bacteria capsules) on antibiotic-associated diarrhea (AAD) secondary to pneumonia in child athletes, with an emphasis on its implications for physical fitness and mental health. Methods: Sixty child players with AAD secondary to pneumonia were randomized into two groups: a probiotics group (receiving Bifidobacterium triple live bacteria capsules) and a combined treatment group (receiving both Vitamin D3 and Bifidobacterium triple live bacteria capsules). An additional cohort of 30 child athletes with pneumonia but without AAD served as the control group. The study measured serum levels of Vitamin D3, diamine oxidase (DAO) activity, D-lactate levels, and intestinal flora (including Bifidobacterium, Escherichia coli, and the Bifidobacterium/E. coli ratio) before and after intervention. Results: The intervention with Vitamin D3 combined with Bifidobacterium triple live bacteria capsules significantly outperformed the probiotics-only treatment in managing AAD secondary to pneumonia. Specifically, the combined approach enhanced Bifidobacterium populations, decreased E. coli numbers, improved the B/E ratio, and significantly reduced DAO activity and D-lactate levels. These findings suggest not only an improvement in gut health but potentially contribute to better physical fitness and mental well-being among the child players. Conclusion: Vitamin D3 supplementation, when combined with probiotic treatment, offers a beneficial approach for child athletes suffering from AAD secondary to pneumonia. This strategy not only addresses gastrointestinal symptoms but also holds promise for supporting overall physical fitness and mental health, essential factors for the development and performance of young athletes.