EXPLORING THE ROLE OF UMBELLIFERONE IN ENHANCING MENTAL HEALTH AND RESILIENCE AMONG ATHLETES: A STUDY ON STRESS MITIGATION VIA THE SIRT1-HMGB1/NF-ΚB PATHWAY

Authors

  • Cheng Xiansong Department of Neurology, Shaanxi Provincial People’s Hospital, Xi’an,710068, China
  • Gao Junqing Department of Neurology, Shaanxi Provincial People’s Hospital, Xi’an,710068, China
  • Lv Hua Department of Neurology, Shaanxi Provincial People’s Hospital, Xi’an,710068, China
  • Li Huanhuan Department of Neurology, Tangdu Hospital, the Fourth Military Medical University, 569Xinsi Road, Xi’an 710038, China

Keywords:

Umbelliferone; chronic unpredictable mild stress (CUMS), HMGB1/NF-κB; Sirt1

Abstract

This study investigates the potential of umbelliferone (Umb) in mitigating depressive-like behaviors induced by chronic unpredictable mild stress (CUMS) in rats, with implications for enhancing mental health and resilience among athletes. Umb at doses of 20 and 40 mg/kg was found to significantly reduce depressive behaviors, as evidenced by increased sucrose consumption and decreased immobility in tail suspension and forced swimming tests. The mechanism appears to involve the down-regulation of the HMGB1/NF-κB pathway through the up-regulation of SIRT1, indicating that Umb may possess effective antidepressant properties useful in sports psychology

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Published

2023-09-23

Issue

Vol. 23 No. 89 (2023): Vol. 23, No. 89, marzo/March 2023

Section

Manuscript