The Value of Preoperative Peripheral Blood Rdw, Nlr, and Plr Detection in the Prognosis Evaluation of Colorectal Cancer and its Correlation with Tnm Staging in Athletes: Implications for Physical Health and Fitness

Abstract

Objective: This study aims to assess the prognostic significance of preoperative peripheral blood Red Cell Distribution Width (RDW), Neutrophil to Lymphocyte Ratio (NLR), and Platelet to Lymphocyte Ratio (PLR) in colorectal cancer, focusing on their association with TNM staging and implications for athletes' physical health and fitness. Methods: The cohort consisted of 101 patients diagnosed with colon cancer and 37 with rectal cancer, treated from April 2017 to March 2018, alongside 5 patients with other tumors and 92 with benign intestinal diseases for comparative analysis. All participants underwent pathological evaluations and peripheral blood RDW, NLR, and PLR measurements. The study aimed to explore the variations in these biomarkers across different disease stages and types, especially considering the unique physiological demands of athletes. Results: No significant differences were observed in RDW, NLR, and PLR levels among the colon cancer, rectal cancer, and other tumor groups (P > 0.05). However, these levels were significantly higher in the benign intestinal disease group compared to the cancer groups (P < 0.05). Enhanced sensitivity, specificity, positive predictive value, and negative predictive value were noted when combining RDW, NLR, and PLR indices (P < 0.05). Notably, RDW, NLR, and PLR levels were significantly higher in stages III and IV compared to stages I and II (P < 0.05), with levels in stage IV exceeding those in stage III (P < 0.05). Factors such as histological type, pathological type, TNM stage, lymph node metastasis, and elevated NLR, PLR, RDW levels were significantly associated with patient prognosis (P < 0.05). Multivariate analysis highlighted that poorly differentiated histological type, advanced stages (III and IV), lymph node metastasis, and abnormal elevations in NLR, PLR, RDW levels significantly impacted prognosis (P < 0.05). Conclusion: Colorectal cancer poses a significant threat to patients' lives, including athletes, impacting their physical health and ability to maintain fitness levels. This study underscores the importance of RDW, NLR, and PLR as prognostic indicators in colorectal cancer, revealing their correlation with disease severity and stage. For athletes, these findings emphasize the necessity of regular health screenings to monitor potential impacts on their physical condition and performance capabilities. The identified biomarkers offer crucial insights for evaluating colorectal cancer progression and tailoring preventive and therapeutic strategies to support athletes' health and fitness journeys