Network Pharmacology Study of Xiaodian Decoction in Enhancing Recovery and Performance in Athletes

Authors

  • Shuoshuo Gao Department of Pediatric, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
  • Zekui Fang Zhujiang Hospital of Southern Medical University
  • Xiaoling Lin Guangzhou University of Traditional Chinese Medicine
  • Feifei Lai Guangzhou University of Traditional Chinese Medicine
  • Jiayi Shan, Baoyi Huang, JianMin Li Guangzhou University of Traditional Chinese Medicine

Keywords:

Henoch, Clinical, Pathogens, Decoction, Numerous

Abstract

Background: Systemic vasculitis affects various populations, including athletes, where inflammation can significantly impact performance and recovery. While traditional Western medicine offers limited treatments, alternative approaches like Xiaodian Decoction are being explored for their broader therapeutic potential. Recent studies highlight the role of the NLRP3 inflammasome in inflammatory diseases but have not extensively explored its interaction with treatments like Xiaodian Decoction in an athletic context.

Purpose: This study aims to utilize network pharmacology to identify the active components of Xiaodian Decoction, analyze their targets related to inflammation and immune modulation in athletes, and investigate the decoction's potential impact on performance and recovery by mediating the NLRP3 inflammasome pathway.

Method: Employing bioinformatics tools such as SwissTargetPrediction and TCMSP, we mapped the interactions between the constituents of Xiaodian Decoction and relevant biological targets. This network pharmacology approach helped clarify the pathways potentially influenced by the decoction, with a focus on athletic health.

Results: Xiaodian Decoction contains several active components, such as quercetin and farcalyl glycol, which may modulate inflammatory responses and immune function. These components interact with cytokines and pathways crucial for inflammatory regulation, including IL-1β, IL-6, TNF, and NOS3, and engage signaling pathways like MAPK/ERK, TNF, and JAK-STAT, which are vital for athletic performance and recovery. The decoction's role in potentially regulating the NLRP3 inflammasome through NOD-like receptor pathways suggests a mechanism by which it could enhance recovery and reduce inflammation in athletes.

Conclusion: Xiaodian Decoction may offer therapeutic benefits for athletes by modulating inflammatory responses and immune function through mechanisms involving the NLRP3 inflammasome. This study provides a foundation for further clinical investigation of Xiaodian Decoction as a supportive treatment in sports medicine, aiming to enhance athletic performance and recovery

 

Downloads

Published

2022-01-03

Issue

Vol. 23 No. 89.1 (2023): Vol. 23, No. 89.1, abril/April 2023

Section

Manuscript