EXPLORING THE ROLE OF CUPROPTOSIS-RELATED GENES IN BREAST CANCER: IMPLICATIONS FOR HEALTH MONITORING IN FEMALE ATHLETES

Abstract

Background: Breast cancer (BRCA), originating from duct epithelial cells, is the most prevalent cancer among women globally, leading in both incidence and cancer-related mortality in 2020. Beyond its clinical significance, the role of copper in various biological processes, including iron absorption, mitochondrial respiration, oxidation resistance, and detoxification, is critical. An imbalance in copper homeostasis has been implicated in a wide range of health issues, from cardiovascular diseases to metabolic syndromes and cancers, including breast cancer. Objective: This study aims to explore the prognostic significance of cuproptosis-related genes in breast cancer, investigating the potential broader implications of copper metabolism for health monitoring and preventive strategies in female athletes, who might be particularly susceptible to shifts in mineral balance due to their physical demands. Methods and Results: Copper functions as an essential co-factor in numerous biological processes; however, excessive levels can become toxic if the finely tuned homeostatic mechanisms are disrupted. This dual role of copper underscores the importance of maintaining a balance, which if disturbed, can lead to severe health implications including cancer. By analyzing the prognostic significance of genes related to cuproptosis in breast cancer, we can gain insights into the broader implications of copper homeostasis in athletic health management. Conclusion: Understanding the role of cuproptosis-related genes in breast cancer provides a gateway to broader applications in sports health management. Monitoring copper levels and related genetic markers could become a crucial aspect of health strategies, aimed at preventing not only cancer but also other copper-related disorders in athletes. This approach emphasizes the need for targeted health strategies that cater to the unique physiological demands of female athletes.