EXPLORING THE NEUROPROTECTIVE EFFECTS OF GINKGOLIDE B IN ALZHEIMER’S DISEASE: IMPLICATIONS FOR ENHANCING COGNITIVE FUNCTION THROUGH THE PI3K/AKT SIGNALING PATHWAY

Authors

  • Li Shao Department of Neurology, The Municipal Hospital Affifiliated to Xuzhou Medical University, Xuzhou First People’s Hospital, Xuzhou, 221116, China.
  • Qing He Department of Neurology, The Municipal Hospital Affifiliated to Xuzhou Medical University, Xuzhou First People’s Hospital, Xuzhou, 221116, China.
  • Xin Du Department of Neurology, The Municipal Hospital Affifiliated to Xuzhou Medical University, Xuzhou First People’s Hospital, Xuzhou, 221116, China.
  • Qing Li Department of Neurology, The Municipal Hospital Affifiliated to Xuzhou Medical University, Xuzhou First People’s Hospital, Xuzhou, 221116, China.
  • Siyuan Yang Department of Neurology, The Municipal Hospital Affifiliated to Xuzhou Medical University, Xuzhou First People’s Hospital, Xuzhou, 221116, China.
  • Chen Dong Department of Neurology, The Municipal Hospital Affifiliated to Xuzhou Medical University, Xuzhou First People’s Hospital, Xuzhou, 221116, China.
  • Pengju Ma Linguistics and Applied Linguistics, School of Liberal Arts, Nanjing Normal University, Nanjing, 210097, China.

Keywords:

Ginkgolide B; Alzheimer's disease; PI3K/AKT signaling pathway; Action mechanism

Abstract

Objective: To investigate the potential of Ginkgolide B (GB) in enhancing cognitive performance and neuroprotection in Alzheimer’s disease through the PI3K/AKT signaling pathway, with implications for physical and cognitive health in athletes. Methods: Male SD rats were divided into a sham operation group, a model group, and three dosage groups (high, medium, and low). Alzheimer's disease models were established in the dosage groups, while the sham group received saline injections. After 4 weeks of treatment, cognitive functions were assessed through escape latency and platform crossing tests, and hippocampal tissues were analyzed for neuronal health, apoptosis, and oxidative stress markers. PI3K and AKT expression levels were quantified using qRT-PCR and Western blot. Results: Compared with the model group, rats in the medium and high dose GB groups showed improved memory and learning capabilities, indicated by reduced escape latency and increased platform crossings. Neuronal integrity in the hippocampal CA3 area was better preserved in these groups, with fewer signs of necrosis and apoptosis. Additionally, oxidative stress markers were normalized, and the expression of PI3K and AKT signaling proteins was significantly enhanced in treated groups. Conclusion: Ginkgolide B significantly enhances cognitive functions, likely through modulation of the PI3K/Akt pathway, suggesting potential benefits for maintaining cognitive health and enhancing performance in scenarios where mental agility and recovery are critical, such as in sports and athletic endeavors.

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Published

2024-02-01

Issue

Vol. 24 No. 96 (2024): Vol. 24, No. 96 junio/June 2024

Section

Manuscript