EVALUATING THE EFFECT OF MAGNOLIA EXTRACT ON GASTROINTESTINAL RECOVERY AND STRESS RESPONSE FOLLOWING SURGERY FOR ACUTE GASTRIC ULCER PERFORATION IN ATHLETES

Abstract

Objective: This study evaluates the efficacy of Magnolia Extract in enhancing gastrointestinal recovery and reducing stress response after surgery for acute gastric ulcer perforation, specifically within an athletic population. Methods: Sixty patients with acute gastric ulcer perforation treated at our hospital from July 2020 to July 2022 were randomly assigned to a control group (n=30), receiving standard laparoscopic repair and postoperative care, and an observation group (n=30), which additionally received Magnolia Extract. Outcomes measured over a 7-day postoperative period included times to first flatus, first bowel movement, and recovery of bowel sounds; levels of motilin (MTL), vasoactive intestinal peptide (VIP), and gastrin (GAS); oxidative stress markers including malondialdehyde (MDA), superoxide dismutase (SOD), and lipid peroxide (LPO); and the rate of postoperative complications. Results: The observation group demonstrated significantly shorter times to first flatus, first bowel movement, and bowel sound recovery (P<0.05). Post-treatment levels of MTL and GAS were significantly increased, and VIP significantly decreased in both groups, with more pronounced changes in the observation group (P<0.05). Additionally, postoperative oxidative stress was better managed in the observation group, with significantly lower levels of MDA and LPO and higher levels of SOD compared to the control group (P<0.05). The incidence of complications was significantly lower in the observation group (3.33%) compared to the control group (20.00%, P<0.05). Conclusion: Administering Magnolia Extract post-surgery for acute gastric ulcer perforation significantly enhances gastrointestinal function, mitigates stress response, and reduces complications, offering a valuable adjunct to standard postoperative care, particularly in athletes where rapid recovery is critical. This approach warrants further investigation for broader clinical application in postoperative care for athletes.