EVALUATING THE PROGNOSTIC SIGNIFICANCE OF BIOCHEMICAL MARKERS IN ATHLETES RECEIVING HEMODIALYSIS: A META-ANALYSIS

Abstract

Objective: This meta-analysis investigates the association between key biochemical markers and all-cause mortality in athletes undergoing hemodialysis, focusing on markers such as ferritin, hemoglobin, calcium, phosphorus, uric acid, and others in relation to their overall health and longevity. Methods: A comprehensive search of databases including PubMed, EMBASE, and Cochrane Library was conducted to collect studies published up to December 2021 that reported on ferritin, hemoglobin, calcium, phosphorus, uric acid, blood pressure, and body mass index (BMI) in hemodialysis patients. The studies were rigorously selected based on inclusion and exclusion criteria, and data were extracted for meta-analysis to evaluate the correlation of these markers with all-cause mortality in athletes. Results: Our analysis included a total of 35 studies encompassing 12,500 patients, of which a subset were identified as athletes. Elevated levels of ferritin and phosphorus were associated with increased mortality rates, while optimal levels of hemoglobin, calcium, and controlled blood pressure were linked to improved survival rates. The role of BMI presented a complex pattern, suggesting a U-shaped relationship with mortality. Conclusion: The findings underscore the critical importance of monitoring specific biochemical markers in athletes undergoing hemodialysis to tailor nutritional and medical interventions that could potentially reduce mortality risks and enhance quality of life. This study highlights the need for targeted health management strategies in the sports medicine community to support the long-term health of athletes on hemodialysis.