EVALUATING SERUM SIRTUIN1 AND CATS LEVELS IN ATHLETES: IMPLICATIONS FOR CAROTID ARTERY HEALTH AND RECOVERY PROGNOSIS POST-ACUTE CEREBRAL INFARCTION

Abstract

Objective: This study investigates the correlation between serum levels of Sirtuin1 and CatS and carotid artery stenosis, as well as their impact on the short-term prognosis in athletes who have experienced an acute cerebral infarction. Methods: A cohort of 110 athletic patients with acute cerebral infarction, admitted to our hospital from January 2018 to January 2020, was examined. Patients were categorized based on the degree of carotid artery stenosis into mild (n = 32), moderate (n = 40), and severe (n = 38) stenosis groups. A control group comprised of 50 healthy individuals undergoing routine physical examinations was also analyzed for baseline comparisons. The study focused on comparing the levels of Sirtuin1 and CatS across these groups and analyzing their associations with athletic patient prognosis and survival rates, alongside other clinical factors such as hypertension and smoking status. Results: Sirtuin1 and CatS levels were significantly higher in athletic patients with acute cerebral infarction compared to healthy controls (P < 0.05), and levels increased with the severity of stenosis (P < 0.05). Of the infarction patients, 73 survived while 37 succumbed, resulting in a survival rate of 66.36%. Survival was associated with factors such as lower infarct size and better compensatory collateral circulation. Notably, higher levels of Sirtuin1 and CatS were linked with poorer outcomes (P < 0.05). Multivariate analysis identified these biomarkers, along with NIHSS score and collateral circulation compensation, as independent predictors of one-year prognosis (P < 0.05). Conclusion: In athletes recovering from acute cerebral infarction, serum levels of Sirtuin1 and CatS correlate significantly with the degree of carotid artery stenosis and are potent independent predictors of prognosis. These biomarkers can serve as critical indicators for tailoring post-infarction rehabilitation strategies in sports medicine, facilitating personalized approaches to enhance recovery and minimize downtime for athletes.