Utilizing Hematologic Biomarkers and PNI in Prognosis Assessment of Targeted Therapy for Advanced Lung Adenocarcinoma: A Sports-Inspired Approach
Keywords:
Neutrophil to lymphocyte ratio, Platelet to lymphocyte ratio, Prognostic nutritional index, Targeting, Lung adenocarcinoma, Prognosis; Sports approach; Athletic patientsAbstract
Objective: In this study, we adopt a Sports-Inspired Approach to investigate the prognostic significance of Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in the peripheral blood of athletic patients diagnosed with advanced lung adenocarcinoma prior to commencing targeted therapy. Additionally, we explore the relationship between Prognostic Nutritional Index (PNI) and overall survival (OS) in this patient cohort.
Methods: We conducted a retrospective analysis of clinical data from 54 athletic patients with pathologically confirmed lung adenocarcinoma who possessed exon 19 or 21 mutations identified through genetic testing. Pre-treatment test results were extracted from medical records, and OS data were collected via medical records or telephone follow-up. Our data analysis encompassed ROC curve analysis, Kaplan-Meier survival curve analysis, log-rank single factor analysis, and Cox multiple factor analysis.
Results: Our findings indicate that gender, age, clinical stage, EGFR mutation type, lymph node metastasis, treatment method, tyrosine kinase inhibitor (TKI) drug, CEA level, CA125 level, PLR level, and PNI level were not correlated with OS. However, we observed statistically significant differences between increased NLR, a history of heavy smoking, and shorter survival. Multivariate regression analysis identified NLR (P=0.042, 95% CI: 0.002-1.023) as an independent factor influencing OS in patients with lung adenocarcinoma following targeted therapy.
Conclusion: Our Sports-Inspired Approach underscores the clinical utility of NLR as a convenient and reliable prognostic indicator for evaluating the outcomes of athletic patients with advanced lung adenocarcinoma following targeted therapy. This novel perspective highlights the importance of integrating sports analogies into the management of these patients and further validates NLR as a valuable predictive biomarker.