EXPLORING THE LINK BETWEEN SERUM TOLL-LIKE RECEPTOR 9 AND 25-HYDROXYVITAMIN D LEVELS IN ATHLETES WITH TYPE 2 DIABETES AND FOOT ULCERS

Abstract

Background: The presence of diabetic foot ulcers (DFUs) in athletes with type 2 diabetes can significantly impede performance and recovery. This study investigates the relationship between serum Toll-like receptor 9 (TLR9) and 25-hydroxyvitamin D levels, which are critical in inflammation and immune regulation, potentially influencing wound healing in this population. Objective: To explore the correlation between TLR9 and 25-hydroxyvitamin D in athletes with type 2 diabetes, aiming to identify potential markers that could guide prevention and treatment strategies for DFUs. Methods: Serum samples from Chinese athletes with type 2 diabetes, both with and without foot ulcers, were analyzed for TLR9 and 25-hydroxyvitamin D levels. The study aimed to determine if these biomarkers could serve as indicators of ulcer risk and recovery potential. Results: Preliminary findings indicate a significant correlation between elevated TLR9 levels and lower 25-hydroxyvitamin D levels in athletes with DFUs compared to those without ulcers. These results suggest an interplay between vitamin D deficiency and increased inflammatory response, which may exacerbate or predispose athletes to DFUs. Conclusion: The study highlights a potential link between inflammation, immune response, and vitamin D status in athletes with type 2 diabetes, affecting their susceptibility to foot ulcers. Recognizing and managing these biomarkers may provide new avenues for preventing and treating DFUs in diabetic athletes, ultimately helping maintain their health and athletic performance. Future research should focus on longitudinal studies to track vitamin D and TLR9 levels in relation to exercise and athletic performance, providing a deeper understanding of their roles in diabetic health management.