AUCUBIN ENHANCES LPS-INDUCED PROLIFERATION AND APOPTOSIS MITIGATION VIA UPREGULATING MICRORNA-9 IN CARTILAGE CELLS: IMPLICATIONS FOR MENTAL AND PHYSICAL HEALTH

Abstract

This research delves into the effects of Aucubin (Au) on LPS-induced inflammation in cartilage cells, with an emphasis on its implications for mental and physical health in osteoarthritis (OA). We analyzed the impact of Au on cell viability, apoptosis, and inflammatory markers, and further explored its regulatory influence on microRNA-9 (miR-9). Our results show that Au effectively mitigates LPS-induced damage in cartilage cells by modulating miR-9, subsequently influencing the NF-κB pathway. This study sheds light on the potential of Au in enhancing both mental and physical health aspects in OA, proposing a novel therapeutic avenue for comprehensive OA management.