ENHANCING NEUROLOGICAL RECOVERY IN ATHLETES: ELECTROACUPUNCTURE’S ROLE IN MITIGATING CEREBRAL ISCHEMIA-REPERFUSION INJURY VIA THE DOR/AKT/GSK-3Β PATHWAY

Abstract

Objective: This study investigates the potential of electroacupuncture (EA) as a therapeutic intervention for cerebral ischemia-reperfusion injury, which athletes might experience following head trauma or severe physical exertion. The research specifically examines EA’s modulation of the DOR/AKT/GSK-3β signaling pathway, known for its role in neuroprotection. Methods: Using a model of cerebral ischemia-reperfusion, we applied EA and monitored changes in the DOR/AKT/GSK-3β pathway. We assessed the neuroprotective effects by measuring neuronal damage markers, inflammation levels, and overall neurological function post-injury. Results: Electroacupuncture treatment significantly reduced markers of neuronal damage and inflammation. It also enhanced the activation of the DOR/AKT/GSK-3β pathway, correlating with improved neurological outcomes and quicker recovery times in the model subjects. Conclusion: Electroacupuncture shows promise as a supportive treatment for athletes recovering from cerebral ischemia-reperfusion injuries, potentially hastening neurological recovery and reducing downtime. By modulating key neuroprotective pathways, EA may help maintain cognitive and motor function post-injury, underscoring its relevance in sports medicine. Future research should explore the applicability of these findings in clinical settings, particularly among athletic populations, to develop tailored neurorehabilitation strategies.