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International Journal of Medicine and Science of Physical Activity and Sport

International Journal of Medicine and Science of Physical Activity and Sport

REVISTA INTERNACIONAL DE MEDICINA Y CIENCIAS DE LA ACTIVIDAD FÍSICA Y EL DEPORTE

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EFFECT OF INTRANEURAL INJECTION OF DIOSMETIN COMBINED WITH LIDOCAINE ON SCIATIC NERVE BLOCK IN RETIRED PLAYERS

Issue Volume 23, Number 91, 2023 Articles 
Wang Li
Ningbo women's and children's Hospital, Ningbo, Zhejiang

Abstract

Objective: To investigate the effect and mechanism of intraneural injection of diosmetin combined with lidocaine on sciatic nerve block in retired players. Methods: Thirty two retired players were randomly divided into four groups: Sham group, diosmetin group (100mg·kg-1) and lidocaine group (10% lidocaine (20μL)) and lidocaine+diosmetin group (10% lidocaine (20μL) and 100mg·kg-1 diosmetin). Then the conduction state of sciatic nerve was detected; The sensory and motor function were assessed; the histopathological changes of sciatic nerve were observed by toluidine blue staining; the gene expression of IL-1βand TNF- α on the mRNA level was detected by RT-PCR. Results: Compared with lidocaine group, lidocaine+diosmetin can better enhance sensory and motor nerve block, reduce histopathological damage of sciatic nerve, and decrease the expression of inflammatory factors, such as IL-1 β And TNF- α in transcriptional level. Conclusion: Diosmetin has the effects of enhancing sensory and motor nerve block, anti-inflammatory and protecting nerve injury.

Keywords: Diosmetin; Sciatic nerve; Nerve block; Retired Players
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Periodicidad Trimestral/Quartely
Revista multidisciplinar de las Ciencias del Deporte
ISSN: 1577-0354
All journal articles are published in Spanish together with their corresponding translation into English

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