Purpose: To examine the impact of cognitive training and trans phenomenal magnetic stimulation (TMS) on cognitive function and imaging indicators in cognitively impaired patients following post-stroke. Method: Seventy-six stroke patients with cognitive impairment admitted to our institution from January 2020 to 12 December 2021 were chosen and classified into different control and study groups depending on the therapy. The treatment was cognitive training for the control group and transcranial magnetic stimulation (TMS) for the study group on top of the treatment for the treatment for the control group. Compare the MoCA, MBI, MMSE scores, treatment effects, serum thyroid hormone levels and lipid index of the two groups. The transverse axial T2W1 and T1W1 scans were performed by MRI, followed by intravenous injection of gadopenate meglumine salt, and repeated transverse scans were performed to evaluate the imaging index of brain edema volume. Result: After treatment, MoCA, MBI and MMSE ratings were markedly higher in both groups, The relationship with the difference for both groups was considered in statistical significance (p<0.05); the overall effective efficiency was higher in the treatment group (92.11%) than in the treatment group (71.05%) (p<0.05); after treatment, Serum thyroid hormone concentrations of T3 and TSH were higher in the study group than in the response group and the variance was considered to be statistically meaningful (p<0.05); Brain edema volume was reduced in both groups, more significantly in case of the investigation group than the response group (p<0.05). With the combined treatment, TCHO, TG and LDL levels decreased in both groups, with an increase in HDL in the research group and a decrease in HDL in the trial group, but they were not markedly different (p>0.05). Conclusion: Cognitive training combined with TMS treatment is conducive to improving the level of serum thyroid hormone and blood lipid of patients, promoting the improvement of cognitive function of patients, and reducing the volume of brain edema. The treatment effect is good. Therefore, cognitive training combined with TMS is worth popularizing.