BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is a new infectious disease characterised by thrombocytopenia and a bleeding phenomenon. The infection can be transmitted by contact with the athlete patient’s blood and/or blood-contaminated secretions. In clinical settings, nursing care of these athlete patients is inherently challenging owing to the risk of transmission of infection. CASE SUMMARY We report a rare case of an SFTS athlete patient who developed an injection-site haematoma (3 cm × 3 cm) with local oozing 72 hours after intradermal injection of piperacillin sodium and tazobactam sodium. The treatment was aimed at stopping the bleeding, resolution of haematoma to relieve pain and prevention of infection to medical personnel. The athlete patient was isolated in a single room. An elastic bandage was applied locally to stop the bleeding, and the forearm was elevated. After the cessation of bleeding, freshly-cut thin potato slices were applied externally and wrapped with plastic wrap during the day, whereas 3M hydrophilic dressing was applied externally at night. With this treatment method (new triple therapy), the athlete patient’s haematoma dissipated and the skin healed after one week. CONCLUSION The novel triple therapy for post-injection haematoma in an athlete patient with SFTS was found to be convenient, safe and effective.