The higher the employee performance, the greater the likelihood of a hospital's success, and conversely, the lower the employee performance, the greater the chance of the hospital's failure. One form of transformational leadership that supports enhanced employee performance is Leader-Member Exchange (LMX) leadership. Employee capabilities such as job crafting are also crucial for achieving the desired performance, as they involve the ability to modify tasks and make the job more meaningful. Furthermore, an individual factor determining employee performance is their dedication to the job, or work engagement. This study aims to determine the influence of Leader-Member Exchange (LMX), job crafting, and work engagement on nurse performance at Dr. Tadjuddin Chalid General Hospital. The research employed a cross-sectional study design, utilizing a sample of 120 nurses and 10 head nurses as respondents. The results of the study indicate that there is a direct influence of Leader-Member Exchange on nurse performance, there is a direct influence of job crafting on nurse performance, there is a direct influence of work engagement on nurse performance, and there is an indirect influence of Leader-Member Exchange on performance through job crafting. However, there is no indirect influence of Leader-Member Exchange on performance through work engagement, there is no indirect influence of job crafting on performance through work engagement, and there is no indirect influence of Leader-Member Exchange on nurse performance through job crafting and work engagement at Dr. Tadjuddin Chalid General Hospital. It is recommended that hospital management encourage the involvement of head nurses in supporting their subordinate nurses, moving beyond merely being a problem-solver. Management should also enhance the individual creativity of nurses in task completion and align job demands with their possessed skills, in addition to creating a comfortable and pleasant working environment in terms of both facilities and infrastructure and relational aspects among nurses.