Background: Noise, workload, and working hours are important factors that can trigger fatigue, which ultimately contributes to work productivity levels. Objective: This study aims to analyze the effect of noise, workload, and working hours on work productivity through work fatigue among workers at PT. Maruki International Indonesia. Methods: This quantitative study used a cross-sectional design with SMART-PLX-based path analysis. Results: The results showed that noise did not significantly affect work fatigue (p=0.834) or work productivity (p=0.342), and work fatigue as a mediator was not significant (p=0.844). physical workload significantly affects work fatigue (p=0.018) and does not affect work productivity (p=0.369), and work fatigue as a mediator is significant (p=0.041), mental workload does not significantly affect work fatigue (p=0.977) and affects work productivity (p=0.010), and work fatigue as a mediator is not significant (p=0.977), length of service significantly affects work fatigue (p=0.016) and does not affect work productivity (p=0.213), and work fatigue as a mediator is significant (p=0.042). Conclusion: Physical workload, mental workload, and length of service are important factors that affect work productivity, both directly and through fatigue as an intervening variable, while noise is not proven to have a significant effect on fatigue or work productivity.