Fatigue is a major occupational health issue that reduces performance, concentration, and safety, especially among mining drivers exposed to long hours, irregular schedules, and high demands. This study analyzed the effects of work stress, working hours, rest duration, and sleep quality on fatigue among Light Vehicle (LV) drivers at PT Cipta Kridatama, BIB Site, South Kalimantan. An analytical observational design with a cross-sectional approach was applied, involving 76 LV drivers selected through proportional total sampling. Data were collected using questionnaires and analyzed with chi-square tests and logistic regression. Results showed that work stress (p=0.000), working hours (p=0.046), rest duration (p=0.009), and sleep quality (p=0.037) were significantly associated with fatigue, while work shift was not (p=0.393). Logistic regression identified work stress as the strongest predictor (p=0.013; OR=8.80), indicating that highly stressed drivers were nearly nine times more likely to experience fatigue. Rest duration also had a protective effect (p=0.019; OR=0.117). Although not statistically significant, longer working hours and poor sleep quality showed a tendency to increase fatigue risk. In conclusion, occupational fatigue among LV drivers is mainly influenced by stress and insufficient rest, highlighting the need for stress management, adequate breaks, and better sleep quality.