Objective: To investigate the effectiveness of synthetical nursing intervention on the quality of life and self-care ability of lung cancer retired athletic patients undergoing surgery. Methods: 72 retired athletic patients with lung cancer and received surgical treatment were research subjects and put into two groups i.e., control group (n=36) and research group (n=36). The control group was given routine nursing intervention while the research group received a comprehensive nursing intervention on top of routine nursing intervention. Serum indexes, quality of life, self-care ability, complication rate and measure for nursing satisfaction were measured in both groups before and after intervention. Results: After the intervention, the serum measure of each index of the two groups were in a higher status than those before the intervention, and the levels of CRP, IL-6, MAP and RR in the research group were lower than those in the control group (P<0.05). The scores of family, relationship with doctors, emotion, function, and lung cancer-related status were all lower than those before intervention, and the ameliorate of quality of life in the research group was better than that in the control group (P<0.05). The scores of disease cognition and self-concept were higher than those before intervention, and the amelioration of self-care ability in the research group was better than that in the other (P<0.05); the incidence of complications in the research group (8.33%) was lower than in the control group (19.44%) (P>0.05). The nursing service satisfaction of the research group was 94.44% and significantly higher than that of the control group at 86.11% (P<0.05). Conclusion: Comprehensive nursing intervention in retired athletic patients with lung cancer surgery are able to elevate the quality of life and self-care ability of retired athletic patients and achieve significant nursing impression which are worthwhile for future clinical application.