This study examined the factors that influence the health promotion behaviors of cancer patients, with a focus on Pender's health promotion model (1996). Fifty patients were asked to complete a standardized questionnaire. employing a model of the smart PLS Algorithm to measure the study analysis. The criteria that predicted the participants' health promotion behavior included social support, commitment to a plan of action, prior behavior, activity-related impacts, perceived self-efficacy, family function, expected benefits of action, and situational influences. The overall explanatory power of these variables is 57.8%. A nursing intervention plan that enhances patient adherence to health promotion behaviors must be created and put into practice if cancer patients undergoing rehabilitation are to maintain their best possible health and have satisfying lives. According to research, patients with low levels of prognostic markers need special care.