Running is a physical activity executed by many individuals globally; it is considered a highly effective exercise promoting health benefits. At the same time, with a lot of benefits running provides, it also causes major injuries that create hindrances to its continuity. A current Meta-analysis demonstrated that the injury rate ranges from 2.5-33.0 per 1000 hours of running, depending on the type of running activity, injury description and duration of follow-up. Running injuries are considered a crucial public health issue, so injury prevention approaches should be highlighted. The research based on primary data analysis to determine these studies used smart PLS software and generated informative results, including descriptive statistical analysis, the confidence interval, and the significant analysis between them. However, it is essential to understand the aetiology of the different factors and mechanisms to reduce the injuries. Injury prevention can be improved if the factors related to injury can be variable biologically. The biomechanical Analysis is related to enhancing performance to increase the body's stability, and better stability leads to effective performance. Secondly, by biomechanical analysis, the strength and power of the body increase, and such strength and power help a lot in maintaining better energy in the body to enhance the performance of the athlete. Overall, research found that biomechanical analysis shows a significant link with them.  By learning from biomechanical Analysis, the body's speed increases because an athlete learns to use its muscles properly to enhance the body's speed.