The study explores the effect of neurobiological research on regular physical activity research based on primary data analysis. These data were collected through different questions related to physical activity and cognitive function. The elderly person is considered a research sample for measuring the study using SPSS software, and the run result included descriptive statistics, model summary, correlation coefficient, and linear regression analysis between neurobiological and cognitive function. Physical activity helps older people to improve their cognitive functions as the release of different growth factors, which include IGF-1, VEGF and BDNF, increases, and these factors pass towards the brain. The cascade of growth factors as a result of physical activity promotes health benefits to brain function. It was demonstrated that while having physical activity, the growth factor BDNF, also secreted from the brain cells and muscle contraction during exercise, promotes the release of myokines, irisin and cathepsin B, which increase the production of growth factors in the hippocampus area of the brain. This improves the cognitive abilities of elderly persons. Overall, the research found a significant neurobiological effect of regular physical activity