Objective: Analyze the "one -step method" laparoscopic biliary tube detection (LCBDE) combined with laparoscopic gallbladder sinking (LC) to treat the effects and safety of gallbladder stones with bile stones (CBDS). Methods: Retrieve Chinese and English databases, collect LCBDE combined with LC to treat gallbladder stones with clinical random control research (RCT). Essence The ending indicators include CBD clearing stones, transit opening rates, stones residual rates, stones recurrence rates, postoperative complications, and postoperative hospitalization. Results: This study has been included in 21 documents. Two groups of CBD Qingshi (OR = 0.78, 95%CI: 0.49, 1.25), stones residue rate (or = 0.73, 95%CI: 0.34, 1.56) There is no statistical difference. The recurrence rate of "one -step method" is significantly lower than the "two -step method" (or = 0.37, 95%CI: 0.20, 0.69), the total incidence of complications was significantly lower (or = 0.66, 95%CI: 0.52, 0.84), shorter after surgery (WMD = -1.07D, 95%CI: -2.00, -0.14). Conclusion: The "one -step method" LCBDE combined with LC treatment of gallbladder stones and CBDS effects are equivalent to ERCP/EST sequential LC, but their postoperative complications have fewer complications. Patients recovery after surgery are a more ideal choice.